1. Symptoms:
Some of the symptoms, which are more common in men, includes:
- Yellow colouring of the skin
- Dark yellow-orange urine
- Fatigue
-Pallor (unhealthy pale appearance) and general deterioration of physical conditions
- Heavy and fast breathing
- Weak and rapid pulse
- Enlarged spleen
Some of the symptoms, which are more common in men, includes:
- Yellow colouring of the skin
- Dark yellow-orange urine
- Fatigue
-Pallor (unhealthy pale appearance) and general deterioration of physical conditions
- Heavy and fast breathing
- Weak and rapid pulse
- Enlarged spleen
2. Diagnosis:
General tests:
Bilirubin level → measure amount of bilirubin
Complete blood count, including red blood cell count → measure amount of RBC
Specific tests:
Phenotypic Diagnostic Test:
This test measures the qualitative and quantitative amount of enzymatic activity by G6PD. Dyes or fluorescent markers are used to indicate the rate of G6PD enzyme in reducing NADP to NADPH. Spectrophotometry is used to detect the conversion of NADP to NADPH.
Molecular Diagnostic Test:
This test identifies the absence or presence of mutations to the G6PD gene itself. Primers specific to the G6PD gene are used. It overcomes the problems of the phenotypic diagnostic test such as varying enzymatic activity and reagent breakdown.
General tests:
Bilirubin level → measure amount of bilirubin
Complete blood count, including red blood cell count → measure amount of RBC
Specific tests:
Phenotypic Diagnostic Test:
This test measures the qualitative and quantitative amount of enzymatic activity by G6PD. Dyes or fluorescent markers are used to indicate the rate of G6PD enzyme in reducing NADP to NADPH. Spectrophotometry is used to detect the conversion of NADP to NADPH.
Molecular Diagnostic Test:
This test identifies the absence or presence of mutations to the G6PD gene itself. Primers specific to the G6PD gene are used. It overcomes the problems of the phenotypic diagnostic test such as varying enzymatic activity and reagent breakdown.
Content references:
http://www.nlm.nih.gov/medlineplus/ency/article/000528.htm
http://www.map.ox.ac.uk/client_media/publications/Howes_G6PDDef_AdvParasit.pdf
http://www.nlm.nih.gov/medlineplus/ency/article/000528.htm
Picture references:
http://www.jaad.org/article/S0190-9622(12)00248-4/fulltext
http://www.reddit.com/r/gifs/comments/22wm1q/heavy_breathing_cat_animated_oc/
http://www.webmd.boots.com/women/ss/slideshow-thyroid-symptoms-and-solutions
http://www.nlm.nih.gov/medlineplus/ency/article/000528.htm
http://www.map.ox.ac.uk/client_media/publications/Howes_G6PDDef_AdvParasit.pdf
http://www.nlm.nih.gov/medlineplus/ency/article/000528.htm
Picture references:
http://www.jaad.org/article/S0190-9622(12)00248-4/fulltext
http://www.reddit.com/r/gifs/comments/22wm1q/heavy_breathing_cat_animated_oc/
http://www.webmd.boots.com/women/ss/slideshow-thyroid-symptoms-and-solutions